Maternal cholestasis and offspring metabolic abnormalities
نویسندگان
چکیده
منابع مشابه
Maternal cholestasis during pregnancy programs metabolic disease in offspring.
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland bi...
متن کاملMaternal obesity and high-fat diet program offspring metabolic syndrome.
OBJECTIVE We determined the potential programming effects of maternal obesity and high-fat (HF) diet during pregnancy and/or lactation on offspring metabolic syndrome. STUDY DESIGN A rat model of maternal obesity was created using an HF diet prior to and throughout pregnancy and lactation. At birth, pups were cross-fostered, thereby generating 4 paradigms of maternal diets during pregnancy/la...
متن کاملMaternal Obesity, Metabolic Health, and Prenatal Programming of Offspring Obesity
Children born to overweight and obese women, as compared to those of normal weight women, have greater risk for becoming obese themselves and suffering comorbid metabolic health problems. Evidence is accumulating that this increased susceptibility is at least partially attributed to a prenatal programming effect, whereby obesogenic factors in the intrauterine environment alter fetal development...
متن کاملMaternal obesity results in offspring prone to metabolic syndrome.
Obesity is reaching epidemic proportions in industrialized and developing countries. The main factors that determine the growing pandemic of obesity are changes in lifestyle leading to a reduced physical activity and increased sedentarism together with an increased richfat food intake. Obesity is a risk factor for many diseases such as type 2 diabetes, cardiovascular risk and stroke, hyperchole...
متن کاملEffect of Maternal Intrahepatic Cholestasis
Thus, the changes in maternal steroid metabolism caused by cholestasis are reflected in the steroid profile of the fetoplacental circulation. Furthermore, maternal intrahepatic cholestasis may result in the production of some substance which crosses the placenta and affects fetal steroid metabolism. Received for publication 7 November 1973 and in revised form 13 February 1974. INTRODUCTION Intr...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2013
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2013.165